Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer’s disease
Abstract
To investigate how serum neurofilament light (NfL) concentration changes through the course of disease in familial Alzheimer's disease (FAD) and to assess when NfL concentration first increases.NfL was measured using an ultrasensitive immunoassay in 117 serum samples from 61 individuals from families with PSEN1 or APP mutations in a longitudinal study (mean ± SD = 1.9 ± 1.1 visits/patient; inter-visit interval = 1.8 ± 1.1 years). The...
Paper Details
Title
Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer’s disease
Published Date
Feb 20, 2019
Volume
11
Issue
1
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