The structure of an iron-containing alcohol dehydrogenase from a hyperthermophilic archaeon in two chemical states

An iron-containing alcohol dehydrogenase (FeADH) from the hyperthermophilic archaeon Thermococcus thioreducens was crystallized in unit cells belonging to space groups P 2 1 , P 2 1 2 1 2 1 and P 4 3 2 1 2, and the crystal structures were solved at 2.4, 2.1 and 1.9 Å resolution, respectively, by molecular replacement using the FeADH from Thermotoga maritima (Schwarzenbacher et al. , 2004) as a model. In the monoclinic and orthorhombic crystals...