Osteoblasts are “educated” by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment
Abstract
In a cancer-free environment in the adult, the skeleton continuously undergoes remodeling. Bone-resorbing osteoclasts excavate erosion cavities, and bone-depositing osteoblasts synthesize osteoid matrix that forms new bone, with no net bone gain or loss. When metastatic breast cancer cells invade the bone, this balance is disrupted. Patients with bone metastatic breast cancer frequently suffer from osteolytic bone lesions that elicit severe bone...
Paper Details
Title
Osteoblasts are “educated” by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment
Published Date
Feb 27, 2019
Journal
Volume
21
Issue
1
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