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Karen M. Bussard
Thomas Jefferson University
36Publications
12H-index
760Citations
Publications 36
Newest
#1Alexus D. Kolb (Thomas Jefferson University)H-Index: 1
#2Alison B. Shupp (Thomas Jefferson University)H-Index: 1
Last.Karen M. Bussard (Thomas Jefferson University)H-Index: 12
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In a cancer-free environment in the adult, the skeleton continuously undergoes remodeling. Bone-resorbing osteoclasts excavate erosion cavities, and bone-depositing osteoblasts synthesize osteoid matrix that forms new bone, with no net bone gain or loss. When metastatic breast cancer cells invade the bone, this balance is disrupted. Patients with bone metastatic breast cancer frequently suffer from osteolytic bone lesions that elicit severe bone pain and fractures. Bisphosphonate treatments are ...
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Bone is a preferential site for cancer metastases, including multiple myeloma, prostate, and breast cancers.The composition of bone, especially the extracellular matrix (ECM), make it an attractive site for cancer cell colonization and survival. The bone ECM is composed of living cells embedded within a matrix composed of both organic and inorganic components. Among the organic components, type I collagen provides the tensile strength of bone. Inorganic components, including hydroxyapatite cryst...
1 CitationsSource
#1Alexus D. KolbH-Index: 1
#2Alison B. ShuppH-Index: 1
Last.Karen M. BussardH-Index: 12
view all 4 authors...
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#1Karen M. Bussard (Thomas Jefferson University)H-Index: 12
#2Alison B. Shupp (Thomas Jefferson University)H-Index: 1
Last.D Mukhopdhyay (Thomas Jefferson University)
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BrCa preferentially metastasizes to bone, where the 5-year relative survival rate is In a cancer-free environment in the adult, the skeleton continuously undergoes remodeling. Osteoclasts excavate erosion cavities and osteoblasts (OB) synthesize bone matrix, with no net bone gain or loss. However, when metastatic BCC invade bone, this balance is disrupted to favor bone loss. Bisphosphonate treatments are not curative. OBs do not deposit new bone. This result suggests that OBs may be altered or e...
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#1Alison B. ShuppH-Index: 1
#2Alexus D. KolbH-Index: 1
Last.Karen M. BussardH-Index: 12
view all 4 authors...
The skeleton is a unique structure capable of providing support for the body. Bone resorption and deposition are controlled in a tightly regulated balance between osteoblasts and osteoclasts with no net bone gain or loss. However, under conditions of disease, the balance between bone resorption and deposition is upset. Osteoblasts play an important role in bone homeostasis by depositing new bone osteoid into resorption pits. It is becoming increasingly evident that osteoblasts additionally play ...
9 CitationsSource
#1Kerith Wang (Thomas Jefferson University)H-Index: 2
#2John A. Abraham (Thomas Jefferson University Hospital)H-Index: 9
Last.William Kevin Kelly (Thomas Jefferson University)H-Index: 31
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e24019Background: While bone is one of the most common sites of metastasis for many cancer types, lack of access to the necessary quantity and quality of human specimens limits the understanding of...
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#1Karen M. Bussard (Thomas Jefferson University)H-Index: 12
#2Linda D. Siracusa (Thomas Jefferson University)H-Index: 34
Alterations in mitochondrial DNA (mtDNA) were once thought to be predominantly innocuous to cell growth. Recent evidence suggests that mtDNA undergo naturally occurring alterations, including mutations and polymorphisms, which profoundly affect the cells in which they appear and contribute to a variety of diseases, including cardiovascular disease, diabetes, and cancer. Furthermore, interplay between mtDNA and nuclear DNA has been found in cancer cells, necessitating consideration of these compl...
9 CitationsSource
#1Frank C. MariniH-Index: 45
#2Julia ChifmanH-Index: 8
Last.Karen M. BussardH-Index: 12
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#1Karen M. Bussard (Wake Forest University)H-Index: 12
#2Lysette A. Mutkus (Wake Forest University)H-Index: 14
Last.Frank C. Marini (Wake Forest University)H-Index: 45
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The tumor microenvironment is a heterogeneous population of cells consisting of the tumor bulk plus supporting cells. It is becoming increasingly evident that these supporting cells are recruited by cancer cells from nearby endogenous host stroma and promote events such as tumor angiogenesis, proliferation, invasion, and metastasis, as well as mediate mechanisms of therapeutic resistance. In addition, recruited stromal cells range in type and include vascular endothelial cells, pericytes, adipoc...
118 CitationsSource
#1Linda D. Siracusa (Thomas Jefferson University)H-Index: 34
#2Karen M. Bussard (Thomas Jefferson University)H-Index: 12
Metastases cause more than 90% of the morbidity and mortality associated with human cancers. Gene expression signatures associated with cancer progression and metastasis serve as unique tools to assist in patient diagnosis, prognosis, and treatment. Various types of signatures have been identified, ranging from those that are tumor-intrinsic or specific to a particular cancer subtype [1] to genes associated with a specific clinical outcome (e.g., “poor prognosis gene signature”) [2], as well as ...
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