Development and Validation of a Novel Flow Cytometric Assay for Quantification of Plasma ADAMTS-13 Activity (AD13a-FCA)
Published: Feb 1, 2019
Abstract
Objectives: ADAMTS-13 is a metalloproteinase that controls the von Willebrand Factor (vWF) multimeric structure by limited proteolysis. Severe ADAMTS-13 deficiency (< 10%), either inherited or acquired, is involved in the pathogenesis of thrombotic thrombocytopenic purpura (TTP), a potentially life threatening disease. The standard of treatment of acute TTP involves plasma infusions / exchange. Currently, recombinant ADAMTS-13 (BAX 930; SHP 655)...
Paper Details
Title
Development and Validation of a Novel Flow Cytometric Assay for Quantification of Plasma ADAMTS-13 Activity (AD13a-FCA)
Published Date
Feb 1, 2019
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