Ubiquitin Ligases in Cancer Immunotherapy – Balancing Antitumor and Autoimmunity

E3 ubiquitin ligases recognize their substrates in a spatial and temporal manner, requiring cell type-specific post-translational modifications that are often affected by the microenvironment (oxygen, nutrients, stress). E3 ubiquitin ligases are important negative regulators of T cell responses that restrain not only autoimmunity but also antitumor immunity. Targeting E3 ubiquitin ligases may be of therapeutic benefit in cancer immunotherapy,...