Partial volume correction for arterial spin labeling using the inherent perfusion information of multiple measurements

Arterial spin labeling (ASL) provides a noninvasive way to measure cerebral blood flow (CBF). The CBF estimation from ASL is heavily contaminated by noise and the partial volume (PV) effect. The multiple measurements of perfusion signals in the ASL sequence are generally acquired and were averaged to suppress the noise. To correct the PV effect, several methods were proposed, but they were all performed directly on the averaged image, thereby...