AMPK-mediated activation of MCU stimulates mitochondrial Ca2+ entry to promote mitotic progression
Abstract
The capacity of cells to alter bioenergetics in response to the demands of various biological processes is essential for normal physiology. The coordination of energy sensing and production with highly energy-demanding cellular processes, such as cell division, is poorly understood. Here, we show that a cell cycle-dependent mitochondrial Ca2+ transient connects energy sensing to mitochondrial activity for mitotic progression. The mitochondrial...
Paper Details
Title
AMPK-mediated activation of MCU stimulates mitochondrial Ca2+ entry to promote mitotic progression
Published Date
Mar 11, 2019
Journal
Volume
21
Issue
4
Pages
476 - 486
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