Original paper
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression
Abstract
The interactions between tumor cells with their microenvironments, including hypoxia, acidosis and immune cells, lead to the tumor heterogeneity which promotes tumor progression. Here, we show that SIAH2-NRF1 axis remodels tumor microenvironment through regulating tumor mitochondrial function, tumor-associated macrophages (TAMs) polarization and cell death for tumor maintenance and progression. Mechanistically, low mitochondrial gene expression...
Paper Details
Title
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression
Published Date
Mar 4, 2019
Journal
Volume
10
Issue
1
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Notes
History