Original paper
Unexpected genomic rearrangements at targeted loci associated with CRISPR/Cas9-mediated knock-in
Abstract
The CRISPR/Cas9 gene editing tool enables accessible and efficient modifications which (re)ignited molecular research in certain species. However, targeted integration of large DNA fragments using CRISPR/Cas9 can still be challenging in numerous models. To systematically compare CRISPR/Cas9’s efficiency to classical homologous recombination (cHR) for insertion of large DNA fragments, we thoroughly performed and analyzed 221 experiments targeting...
Paper Details
Title
Unexpected genomic rearrangements at targeted loci associated with CRISPR/Cas9-mediated knock-in
Published Date
Mar 5, 2019
Journal
Volume
9
Issue
1
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Notes
History