The Association Between Vitamin D and Multiple Sclerosis Risk: 1,25(OH)2D3 Induces Super-Enhancers Bound by VDR

A super-enhancer (SE) is a cluster of enhancers with a relatively high density of particular chromatin features. SEs typically regulate key genes that can determine cell identity and differentiation. Therefore, identifying SEs and their effects may be critical in predicting key regulatory genes, such as master transcription factor genes or oncogenes. The concept of signal inducible SE has been developed to describe dense stretches of signal...