Original paper

Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling

Volume: 55, Issue: 30, Pages: 4311 - 4314
Published: Jan 1, 2019
Abstract
Herein we provide a mass spectrometry-based lysine reactivity profiling strategy to monitor the ligand modulation of protein receptors, which is achieved by active dimethyl labeling of lysine residues and comparison of the alterations of labeling reactivity during ligand binding. The small-molecule ligand modulation patterns on the catechol-O-methyltransferase and the N-methyl-d-aspartate receptors have been predicted, including both binding...
Paper Details
Title
Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling
Published Date
Jan 1, 2019
Volume
55
Issue
30
Pages
4311 - 4314
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