Icons / Logo / Facebook Created with Sketch. Icons / Logo / Google Created with Sketch. Icons / Logo / ORCID Created with Sketch. Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!

In vitro anthelmintic effect of biologically synthesized silver nanoparticles on liver amphistome, Gigantocotyle explanatum

Published on Mar 1, 2019in Experimental Parasitology 1.72
· DOI :10.1016/j.exppara.2019.02.005
Abdur Rehman3
Estimated H-index: 3
(AMU: Aligarh Muslim University),
Rizwan Ullah4
Estimated H-index: 4
(AMU: Aligarh Muslim University)
+ 3 AuthorsS. M. A. Abidi7
Estimated H-index: 7
(AMU: Aligarh Muslim University)
Cite
Abstract
Abstract In order to ensure global food security a rationale approach is required to control all those factors which directly or indirectly affect the food productivity. The neglected helminthic diseases alone are responsible for huge economic losses to the agrarian stakeholders. The problem is further compounded by the emerging drug resistance in flukes against the commonly used anthelmintics like triclabendazole. Therefore, the search for alternatives including the nano-based approaches has become a necessity to develop future control strategies. In the present study the effect of biologically synthesized silver nanoparticles (AgNPs) was investigated on an economically important amphistome parasite, Gigantocotyle explanatum, obtained from the infected liver of the Indian water buffaloes, Bubalus bubalis . In vitro treatment of the adult worms with different doses of AgNPs severely affected the worm motility and caused ROS mediated damages in the treated flukes. The antioxidant system and the detoxification ability of the worms appeared to be disrupted along with pronounced DNA damage in the treated worms as compared to the controls. Following the treatment of worms with different concentrations of AgNPs there was a significant (p  in vivo .
  • References (50)
  • Citations (0)
Cite
References50
Newest
Published on Apr 6, 2018in Journal of Proteome Research 3.78
Joana Carrola6
Estimated H-index: 6
(University of Aveiro),
Ricardo J.B. Pinto14
Estimated H-index: 14
(University of Aveiro)
+ 5 AuthorsIola F. Duarte29
Estimated H-index: 29
(University of Aveiro)
The expansion of biomedical and therapeutic applications of silver nanoparticles (AgNPs) raises the need to further understand their biological effects on human cells. In this work, NMR metabolomics has been applied to reveal the metabolic effects of AgNPs toward human hepatoma (HepG2) cells, which are relevant with respect to nanoparticle accumulation and detoxification. Cellular responses to widely disseminated citrate-coated AgNPs (Cit30) and to emergent biogenic AgNPs prepared using an aqueo...
Published on Jan 1, 2018in International Journal of Biological Macromolecules 4.78
Mohammad Shakir22
Estimated H-index: 22
(AMU: Aligarh Muslim University),
Iram Zia2
Estimated H-index: 2
(AMU: Aligarh Muslim University)
+ 1 AuthorsRizwan Ullah4
Estimated H-index: 4
(AMU: Aligarh Muslim University)
Abstract In this communication we describe the fabrication of nano-hydroxyapatite/chitosan-tamarind seed polysaccharide (n-HA/CS-TSP) nanocomposite with a weight ratio of 70/20/10, 70/15/15 and 70/10/20, respectively through a co-precipitation method. A comparative assessment of the properties of n-HA/CS-TSP and n-HA/CS nanocomposites was done by FT-IR, SEM–EDX, TEM, TGA/DTA, XRD and mechanical testing. The results suggested strong chemical interactions between the three components, decreased pa...
Published on Dec 1, 2017in Experimental Parasitology 1.72
Abdur Rehman3
Estimated H-index: 3
(AMU: Aligarh Muslim University),
Rizwan Ullah4
Estimated H-index: 4
(AMU: Aligarh Muslim University)
+ 5 AuthorsS. M. A. Abidi7
Estimated H-index: 7
(AMU: Aligarh Muslim University)
Abstract The helminth parasites possess great capabilities to adapt themselves within their hosts and also develop strategies to render the commonly used anthelmintics ineffective leading to the development of resistance against these drugs. Besides using anthelmintics the natural products have also been tested for their anti-parasitic effects. Therapeutic efficacy of honey bee venom (HBV) has been tested in various ailments including some protozoal infections but very little is known about its ...
Published on Nov 1, 2017in Sensing and bio-sensing research
Imran Uddin9
Estimated H-index: 9
(AMU: Aligarh Muslim University),
Khateeb Ahmad1
Estimated H-index: 1
(AMU: Aligarh Muslim University)
+ 1 AuthorsMohd Alim Kazmi1
Estimated H-index: 1
(AMU: Aligarh Muslim University)
Abstract Silver (Ag) nanoparticles comprise a highly selective approach for development of nanosensors for the detection of Hg 2 + ions. When Ag nanoparticles mixes with Hg 2 + ions, loses its UV–Vis absorption intensity. Here, green synthesis of Ag nanoparticles was done using plant extract of Matricaria recutita (Babunah) under ambient conditions. Biosynthesized Ag nanoparticles are well-dispersed having quasi-spherical shape and average particle size of 11 nm. XRD, SAED and HRTEM analysis sho...
Published on Oct 3, 2017in PLOS ONE 2.78
M. A. Hannan Khan3
Estimated H-index: 3
(AMU: Aligarh Muslim University),
Rizwan Ullah4
Estimated H-index: 4
(AMU: Aligarh Muslim University)
+ 3 AuthorsS. M. A. Abidi7
Estimated H-index: 7
(AMU: Aligarh Muslim University)
The digenetic trematode Fasciola gigantica is a parasite of great agricultural and economic importance. Along with Fasciola hepatica, F. gigantica incurs huge economic losses to the agricultural sector. Because of unavailability of an effective and commercial vaccine, the earliest diagnosis of the disease is the only way to control the disease. The conventional coprological techniques are able to detect the disease only after the parasites get matured and starts releasing their eggs with the fae...
Published on Sep 1, 2017in Microbial Pathogenesis 2.58
Mohammad Ahmad12
Estimated H-index: 12
(KSU: King Saud University),
Murad A. Mubaraki4
Estimated H-index: 4
(KSU: King Saud University),
Mohammed Ali M. Marie6
Estimated H-index: 6
(KSU: King Saud University)
Abstract Helminth infections in general and digenetic trematodes in particular cause a huge economic loss globally to our livestock. Gigantocotyle explanatum is a digenetic amphistome that infects the bile ducts of water buffalo and are highly prevalent in tropical and sub-tropical countries. In the present study, effects of an organophosphate compound, Metrifonate (MF) in three doses, viz., 9.4 × 10 −5 M (Dose I), 14.4 × 10 −5 M (Dose II), and 19.4 × 10 −5 M (Dose III), have been studied in vit...
Published on Jul 1, 2017in Journal of Helminthology 1.44
R.S. Tomar1
Estimated H-index: 1
,
S. Preet1
Estimated H-index: 1
The present study focuses on the in vitro anthelmintic activity of silver nanoparticles (AgNPs) synthesized using the aqueous extract of Azadirachta indica against Haemonchus contortus. The synthesized AgNPs were characterized by ultraviolet-visible (UV-Vis) spectrophotometry, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD) studies. The UV-Vis spectrum exhibited a sharp peak at 420 nm, which was validated by electron microscopy, indicating t...
Published on Jun 1, 2017in Journal of Parasitic Diseases
M. A. Hannan Khan3
Estimated H-index: 3
(AMU: Aligarh Muslim University),
P. A. A. Shareef1
Estimated H-index: 1
(AMU: Aligarh Muslim University)
+ 3 AuthorsS. M. A. Abidi7
Estimated H-index: 7
(AMU: Aligarh Muslim University)
A number of parasitic platyhelminthes are known to cause genotoxicity in humans and animals. However no such information is available on tropical liver fluke, Fasciola gigantica, which incurs huge economic losses worldwide. In the present study the genotoxic potential of F. gigantica infection in rabbits, experimentally infected with the metacercarial cysts of this parasite, has been investigated using the standard comet assay and micronucleus (MNi) test on the isolated hepatocytes and the whole...
Published on Feb 2, 2017in PLOS ONE 2.78
Rizwan Ullah4
Estimated H-index: 4
,
Abdur Rehman3
Estimated H-index: 3
+ 6 AuthorsS. M. A. Abidi7
Estimated H-index: 7
Fasciolosis an economically important global disease of ruminants in the temperate and tropical regions, caused by Fasciola hepatica and F. gigantica, respectively, also poses a potential zoonotic threat. In India alone it causes huge losses to stakeholders. Anthelmintics including triclabendazole have been used to control this menace but the emerging resistance against the available compounds necessitates identification of novel and alternative therapeutic measures involving plant derived natur...
Published on Jun 1, 2016in Trends in Parasitology 8.02
Jane M. Kelley2
Estimated H-index: 2
(La Trobe University),
Timothy P. Elliott6
Estimated H-index: 6
+ 3 AuthorsTerry W. Spithill43
Estimated H-index: 43
(La Trobe University)
Triclabendazole (TCBZ) is the only chemical that kills early immature and adult Fasciola hepatica (liver fluke) but widespread resistance to the drug greatly compromises fluke control in livestock and humans. The mode of action of TCBZ and mechanism(s) underlying parasite resistance to the drug are not known. Due to the high prevalence of TCBZ resistance (TCBZ-R), effective management of drug resistance is now critical for sustainable livestock production. Here, we discuss the current status of ...
Cited By0
Newest