Hyperandrogenic origins of polycystic ovary syndrome – implications for pathophysiology and therapy

Polycystic ovary syndrome (PCOS) diagnosis comprises combinations of female hyperandrogenism, menstrual irregularity and polycystic ovaries. While it is a familial and highly prevalent endocrine disorder, progress towards a cure is hindered by absence of a definitive pathogenic mechanism and lack of an animal model of naturally occurring PCOS.These include an overview of PCOS and its potential etiology, and an examination of insights gained into...