Variation of High-Sensitivity Troponin T Results in Patients Undergoing Continuous Renal Replacement Therapy:
Published on Jan 1, 2019in Canadian journal of kidney health and disease
· DOI :10.1177/2054358119828386
Background:Cardiac troponins are the preferred biomarker to diagnose myocardial injury. Complicating the interpretation of serial troponins in patients with end-stage renal disease, it has been shown that the hemodialysis procedure results in a small but significant decline in high-sensitivity cardiac troponins (hs-cTnT). This raises the possibility that continuous renal replacement therapy (CRRT) might similarly alter cardiac troponin levels and affect their interpretation when cardiac ischemia is being considered.Objective:We sought to determine the effect of CRRT on hs-cTnT levels over time in a group of patients without active myocardial injury.Design:Prospective, observational studySetting:Single tertiary care hospital, Montreal, QuebecPatients:Ten critically ill patients with acute kidney injury (AKI) undergoing CRRT. Cardiac ICU (intensive care unit) patients and acute coronary syndrome patients were excluded from the study. The CRRT prescription was at the discretion of the treating intensivist an...