Peptidic degron for IMiD-induced degradation of heterologous proteins

Significance Systems for degrading proteins at will are useful for a variety of biological experiments. Although a number of such systems have been described, they vary widely in terms of complexity, ease of obtaining the necessary reagents, and costs. Moreover, no one system seems to work for all proteins, and the ideal system often must be determined empirically. Thalidomide-like drugs (IMiDs) reprogram the ubiquitiously expressed cereblon...