Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
Abstract
An array of carbohydrates masks the HIV-1 surface protein Env, contributing to the evasion of humoral immunity. In most HIV-1 isolates 'glycan holes' occur due to natural sequence variation, potentially revealing the underlying protein surface to the immune system. Here we computationally design epitopes that mimic such surface features (carbohydrate-occluded neutralization epitopes or CONE) of Env through 'epitope transplantation', in which the...
Paper Details
Title
Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
Published Date
Feb 27, 2019
Journal
Volume
10
Issue
1
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