The mode of anesthesia influences outcome in mouse models of arterial thrombosis

Arterial thrombosis models are important for preclinical evaluation of antithrombotics but how anesthetic protocol can influence experimental results is not studied.We studied how three most commonly used rodent anesthetics affect the induction of thrombosis and thrombus resolution with antiplatelet agent integrilin (Eptifibatide).The Folts, electrolytic, and FeCl3 models of carotid artery thrombosis were evaluated. The extent of blood flow...