Original paper

Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy

Volume: 10, Issue: 1
Published: Feb 8, 2019
Abstract
Genomic changes observed across treatment may result from either clonal evolution or geographically disparate sampling of heterogeneous tumors. Here we use computational modeling based on analysis of fifteen primary breast tumors and find that apparent clonal change between two tumor samples can frequently be explained by pre-treatment heterogeneity, such that at least two regions are necessary to detect treatment-induced clonal shifts. To...
Paper Details
Title
Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
Published Date
Feb 8, 2019
Volume
10
Issue
1
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