Original paper
Gene silencing based on RNA-guided catalytically inactive Cas9 (dCas9): a new tool for genetic engineering in Leptospira
Abstract
Leptospirosis is a worldwide zoonosis caused by pathogenic bacteria of the genus Leptospira , which also includes free-living saprophyte strains. Many aspects of leptospiral basic biology and virulence mechanisms remain unexplored mainly due to the lack of effective genetic tools available for these bacteria. Recently, the type II CRISPR/Cas system from Streptococcus pyogenes has been widely used as an efficient genome engineering tool in...
Paper Details
Title
Gene silencing based on RNA-guided catalytically inactive Cas9 (dCas9): a new tool for genetic engineering in Leptospira
Published Date
Feb 12, 2019
Journal
Volume
9
Issue
1
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Notes
History