miRs-206-3p and -381-3p Regulated Calcineurin-NFAT Signaling Upregulates Induced Nitric Oxide Synthase (iNOS) Transcription After 4,4’-Methylene Diphenyl Diisocyanate Exposure

Occupational exposure to the most widely used monomeric diisocyanate, 4,4’-methylene diphenyl diisocyanate (MDI), is a cause of occupational asthma (OA). Fractional exhaled nitric oxide (FeNO) is a putative biomarker for asthma and has been reported to be elevated in MDI-OA patients. However, the mechanism(s) by which MDI exposure causes increased FeNO is currently unknown. Circulating microRNAs (miRs)-206-3p and -381-3p are downregulated after...