Original paper
Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes
Abstract
Hypoxia is a common and prominent feature of the microenvironment at sites of bacteria-associated inflammation in inflammatory bowel disease. The prolyl-hydroxylases (PHD1/2/3) and the asparaginyl-hydroxylase factor-inhibiting HIF are oxygen-sensing enzymes that regulate adaptive responses to hypoxia through controlling the activity of HIF and NF-κB–dependent transcriptional pathways. Previous studies have demonstrated that the pan-hydroxylase...
Paper Details
Title
Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes
Published Date
Mar 1, 2019
Journal
Volume
202
Issue
5
Pages
1521 - 1530
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Notes
History