Large-scale analysis of RNA-DNA interactions

We have performed large-scale analysis of RNADNA contacts in chromatin based on our own experimental data for K562 human cells and GRID-Seq. We have devised RNA-Seq controls and validated the resulting interactions with known chromatin-associated RNAs. We propose a pipeline for the analysis of RNA-DNA interactions, a noise correction procedure and clustering by the distance preference approach. We have compared the obtained interactomes with...