Anastasia Zharikova
Publications 7
#1Vasily RamenskyH-Index: 19
#2Anna J. Jasinska (UCLA: University of California, Los Angeles)H-Index: 21
Last.Mark Cline (Wake Forest University)H-Index: 8
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Genome sequencing studies of nonhuman primate (NHP) pedigree and population samples are discovering variants on a large and rapidly growing scale. These studies are increasing the utility of several NHP species as model systems for human disease. In particular, by identifying homozygous protein truncating variants (hPTVs) in genes hypothesized to play a role in causing human diseases, it may be possible to elucidate mechanisms for the phenotypic impact of such variants through investigations tha...
The clinical, instrumental and molecular-genetic studies for proband and family members for identification of family form of left ventricular noncompaction cardiomyopathy (LVNC) presented in the article. According to the results of the examination, the diagnosis LVNC was made. Drug therapy was adjusted, and a cardioverter defibrillator was implanted for the primary prevention of sudden cardiac death. Given the hereditary nature of the disease, family screening was conducted. By the family screen...
#1Aleksandra A. Galitsyna (Skolkovo Institute of Science and Technology)H-Index: 3
#2Anastasia Zharikova (MSU: Moscow State University)H-Index: 1
Last.Alexey A. GavrilovH-Index: 16
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We have performed large-scale analysis of RNADNA contacts in chromatin based on our own experimental data for K562 human cells and GRID-Seq. We have devised RNA-Seq controls and validated the resulting interactions with known chromatin-associated RNAs. We propose a pipeline for the analysis of RNA-DNA interactions, a noise correction procedure and clustering by the distance preference approach. We have compared the obtained interactomes with DNA-DNA contacts (Hi-C) for the same cell line and rep...
#1Daria Potashnikova (MSU: Moscow State University)H-Index: 6
#2S. A. Golyshev (MSU: Moscow State University)H-Index: 5
Last.Ivan A. Vorobjev (NU: Nazarbayev University)H-Index: 25
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#1A. I. Rytova (MSU: Moscow State University)H-Index: 1
#2E. Yu. Khlebus (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
Last.E. B. Yarovaya (MSU: Moscow State University)H-Index: 10
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Complex diseases are a major important problem for modern medicine. These diseases arise under the influence of specific environmental and clinical-demographic factors, so-called risk factors, in combination with factors of genetic heredity. The contribution of genetic factors to the development of complex diseases is on average about 50%. The cause of complex diseases can be a lot of variants of the nucleotide sequence. In addition to common variants of single nucleotide polymorphisms (SNPs), r...