Original paper

Development of an amorphous nanosuspension by sonoprecipitation-formulation and process optimization using design of experiment methodology

Volume: 559, Pages: 348 - 359
Published: Mar 1, 2019
Abstract
A Design of Experiment (DoE) methodology was adopted to investigate and optimize process parameters and formulations variables for preparing an amorphous clotrimazole (CLT) nanosuspension by sonoprecipitation technique. The amorphous nanosuspension can provide a synergistic effect of increase in dissolution velocity and kinetic solubility which can be advantageously used to improve bioavailability of low-solubility drugs. A Box-Behnken design...
Paper Details
Title
Development of an amorphous nanosuspension by sonoprecipitation-formulation and process optimization using design of experiment methodology
Published Date
Mar 1, 2019
Volume
559
Pages
348 - 359
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