Distinct Interactions of Sodium and Calcium Cations and Neutral Phospholipid Membranes and How to Simulate Them

Metal cations adsorption to cellular membranes, such as sodium and calcium, change many crucial biological functions. Few examples are the interaction with charged moieties, cell membrane potential, membrane fusion or cell volume. They do this by altering membrane ordering, head group region presentation and surface charge in different ways. Currently, it is unclear how or whether cells regulate cations adsorption and hence the related functions...