doi.org/10.1016/j.bbrc.2019.02.013
Original paper

PPARβ/δ agonist GW501516 inhibits TNFα-induced repression of adiponectin and insulin receptor in 3T3-L1 adipocytes

..., Su-Nam Kim
28
Biochemical and Biophysical Research Communications2.50
Published: Mar 1, 2019
Abstract
Previous reports have shown that PPARβ/δ agonists ameliorate insulin resistance associated with type 2 diabetes mellitus (T2DM). To determine the role of PPARβ/δ in tumor necrosis factor α (TNFα)-mediated insulin resistance, we investigated expression levels of adiponectin and insulin receptor (IR) in response to treatment with the PPARβ/δ agonist GW501516 with or without TNFα, a proinflammatory cytokine, in differentiated 3T3-L1 adipocytes....
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Paper Details
Title
PPARβ/δ agonist GW501516 inhibits TNFα-induced repression of adiponectin and insulin receptor in 3T3-L1 adipocytes
DOI
doi.org/10.1016/j.bbrc.2019.02.013
Published Date
Mar 1, 2019
Journal
Biochemical and Biophysical Research Communications
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