Cancer immunotherapy with check point inhibitor can cause autoimmune adverse events due to loss of Treg homeostasis
Abstract
Regulatory T-cells (Tregs) can facilitate immune evasion by tumor cells by dampening anti-tumor immunity. Reduced Teff/Treg ratio and enhanced Treg functional activity have been observed in patients suffering from different types of cancers, and attenuated Treg numbers/functions can serve as prognostic indicators. Normally, Tregs play an essential role in the maintenance of immune tolerance and prevention of autoimmunity. The most common immune...
Paper Details
Title
Cancer immunotherapy with check point inhibitor can cause autoimmune adverse events due to loss of Treg homeostasis
Published Date
Aug 1, 2020
Journal
Volume
64
Pages
29 - 35
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