Propofol suppresses oxidative stress in gliomas through down-regulating divalent metal transporter 1

Oxidative stress enhances tumour invasion and metastasis, in particular in brain cancer, and the activation of divalent metal transporter 1 (DMT1), which is regulated by glutamate receptors, can result in an increase of oxidative stress and cancer risk1. Propofol, an anaesthetic with antioxidant capacity, has been shown to reduce oxidative stress in several cancers although the underlying mechanism is unclear2,3. We thus hypothesised that...