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Perspectives on the expansion of human precision oncology and genomic approaches to sea turtle fibropapillomatosis

Published on Feb 7, 2019
· DOI :10.1038/s42003-019-0301-1
David J. Duffy (Whitney Laboratory for Marine Bioscience), Mark Q. Martindale58
Estimated H-index: 58
(Whitney Laboratory for Marine Bioscience)
Abstract
Our recent Communications Biology research article revealed the genomic drivers and therapeutic vulnerabilities of sea turtle fibropapillomatosis tumors. Fibropapillomatosis is a debilitating tumorous disease afflicting populations of green sea turtles globally. While a virus is involved in the development of this disease, it is increasingly understood that the key trigger is linked to anthropogenic disturbances of the environment. The specific environmental co-trigger(s) has yet to be functionally confirmed. Here we outline the next steps required to advance our understanding of this enigmatic disease, to enable us to more effectively clinically combat it and to ultimately tackle its environmental co-trigger to halt and hopefully reverse the spread of fibropapillomatosis.
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Published on Dec 1, 2018
Mathew Seymour10
Estimated H-index: 10
(Bangor University),
Isabelle Durance17
Estimated H-index: 17
(Cardiff University)
+ 11 AuthorsMark de Bruyn17
Estimated H-index: 17
(USYD: University of Sydney)
Accurate quantification of biodiversity is fundamental to understanding ecosystem function and for environmental assessment. Molecular methods using environmental DNA (eDNA) offer a non-invasive, rapid, and cost-effective alternative to traditional biodiversity assessments, which require high levels of expertise. While eDNA analyses are increasingly being utilized, there remains considerable uncertainty regarding the dynamics of multispecies eDNA, especially in variable systems such as rivers. H...
22 Citations Source Cite
Published on Dec 1, 2018
David J. Duffy8
Estimated H-index: 8
(Bangor University),
Christine E. Schnitzler16
Estimated H-index: 16
(UF: University of Florida)
+ 10 AuthorsBette Zirkelbach1
Estimated H-index: 1
(Marathon Oil)
Wildlife populations are under intense anthropogenic pressures, with the geographic range of many species shrinking, dramatic reductions in population numbers and undisturbed habitats, and biodiversity loss. It is postulated that we are in the midst of a sixth (Anthropocene) mass extinction event, the first to be induced by human activity. Further, threatening vulnerable species is the increased rate of emerging diseases, another consequence of anthropogenic activities. Innovative approaches are...
3 Citations Source Cite
Published on Oct 1, 2018in Nature Reviews Cancer 42.78
Patricia A. Pesavento25
Estimated H-index: 25
(UC Davis: University of California, Davis),
Dalen Agnew13
Estimated H-index: 13
(MSU: Michigan State University)
+ 1 AuthorsKevin D. Woolard14
Estimated H-index: 14
(UC Davis: University of California, Davis)
Cancer is ubiquitous in wildlife, affecting animals from bivalves to pachyderms and cetaceans. Reports of increasing frequency demonstrate that neoplasia is associated with substantial mortality in wildlife species. Anthropogenic activities and global weather changes are shaping new geographical limitations for many species, and alterations in living niches are associated with visible examples of genetic bottlenecks, toxin exposures, oncogenic pathogens, stress and immunosuppression, which can a...
2 Citations Source Cite
Published on Aug 1, 2018in Journal of Virological Methods 1.76
Narges Mashkour2
Estimated H-index: 2
(JCU: James Cook University),
Alicia Maclaine2
Estimated H-index: 2
(JCU: James Cook University)
+ 1 AuthorsEllen Ariel13
Estimated H-index: 13
(JCU: James Cook University)
The number of reptilian viruses detected are continuously increasing due to improvements and developments of new diagnostic techniques. In this case we used primary cell culture and qPCR to describe the first Australian Chelonia mydas papillomavirus. Commercial chelonian cell lines are limited to one cell line from a terrestrial turtle (Terrapene Carolina). To establish primary cultures from green turtles (Chelonia mydas), turtle eggs were collected from Heron Island, Queensland, Australia. From...
1 Citations Source Cite
Published on Jul 1, 2018in Nature Ecology and Evolution
Mathieu Giraudeau15
Estimated H-index: 15
(University of Exeter),
Tuul Sepp12
Estimated H-index: 12
(ASU: Arizona State University)
+ 2 AuthorsFrédéric Thomas40
Estimated H-index: 40
Based on the abundant studies available on humans showing clear associations between rapid environmental changes and the rate of neoplasia, we propose that human activities might increase cancer rate in wild populations through numerous processes. Most of the research on this topic has concentrated on wildlife cancer prevalence in environments that are heavily contaminated with anthropogenic chemicals. Here, we propose that human activities might also increase cancer rate in wild populations thr...
6 Citations Source Cite
Published on Apr 1, 2018in Cancer Cell 22.84
Maximilian Stammnitz3
Estimated H-index: 3
(University of Cambridge),
Tim Hh Coorens1
Estimated H-index: 1
(University of Cambridge)
+ 23 AuthorsSyd Barthorpe17
Estimated H-index: 17
(Wellcome Trust Sanger Institute)
Transmissible cancers are clonal lineages that spread through populations via contagious cancer cells. Although rare in nature, two facial tumor clones affect Tasmanian devils. Here we perform comparative genetic and functional characterization of these lineages. The two cancers have similar patterns of mutation and show no evidence of exposure to exogenous mutagens or viruses. Genes encoding PDGF receptors have copy number gains and are present on extrachromosomal double minutes. Drug screening...
15 Citations Source Cite
Published on Feb 20, 2018in PeerJ 2.12
Cheryl L. Morrison14
Estimated H-index: 14
(USGS: United States Geological Survey),
Luke R. Iwanowicz20
Estimated H-index: 20
(USGS: United States Geological Survey)
+ 7 AuthorsRobert S. Cornman10
Estimated H-index: 10
(USGS: United States Geological Survey)
7 Citations Source Cite
Published on Dec 1, 2017in Genome Medicine 8.90
David J. Duffy8
Estimated H-index: 8
,
Aleksandar Krstic8
Estimated H-index: 8
(UCD: University College Dublin)
+ 5 AuthorsWalter Kolch76
Estimated H-index: 76
(UCD: University College Dublin)
Background Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. Therefore, we employed a precision medicine approach to globally profile the retinoid signalling response and to determine how an excess of cellular MYCN antagonises these signalling events to prevent differentiation and confer re...
6 Citations Source Cite
Published on Oct 18, 2017in PLOS ONE 2.77
Caspar A. Hallmann7
Estimated H-index: 7
(Radboud University Nijmegen),
Martin Sorg1
Estimated H-index: 1
+ 9 AuthorsThomas Hörren1
Estimated H-index: 1
Global declines in insects have sparked wide interest among scientists, politicians, and the general public. Loss of insect diversity and abundance is expected to provoke cascading effects on food webs and to jeopardize ecosystem services. Our understanding of the extent and underlying causes of this decline is based on the abundance of single species or taxonomic groups only, rather than changes in insect biomass which is more relevant for ecological functioning. Here, we used a standardized pr...
234 Citations Source Cite
Published on Sep 1, 2017in Journal of Virology 4.37
Thierry M. Work32
Estimated H-index: 32
(USGS: United States Geological Survey),
Julie Dagenais5
Estimated H-index: 5
(USGS: United States Geological Survey)
+ 2 AuthorsMathias Ackermann37
Estimated H-index: 37
ABSTRACT Fibropapillomatosis (FP) is a tumor disease of marine turtles associated with chelonid herpesvirus 5 (ChHV5), which has historically been refractory to growth in tissue culture. Here we show, for the first time, de novo formation of ChHV5-positive intranuclear inclusions in cultured green turtle cells, which is indicative of active lytic replication of the virus. The minimal requirements to achieve lytic replication in cultured cells included (i) either in vitro cultures of ChHV5-positi...
4 Citations Source Cite
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