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Mark Q. Martindale
Whitney Laboratory for Marine Bioscience
232Publications
58H-index
13.7kCitations
Publications 232
Newest
Published on Feb 7, 2019
David J. Duffy (Whitney Laboratory for Marine Bioscience), Mark Q. Martindale58
Estimated H-index: 58
(Whitney Laboratory for Marine Bioscience)
Our recent Communications Biology research article revealed the genomic drivers and therapeutic vulnerabilities of sea turtle fibropapillomatosis tumors. Fibropapillomatosis is a debilitating tumorous disease afflicting populations of green sea turtles globally. While a virus is involved in the development of this disease, it is increasingly understood that the key trigger is linked to anthropogenic disturbances of the environment. The specific environmental co-trigger(s) has yet to be functiona...
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Published on May 24, 2019in National Science Review 9.41
Xiaocui Xu2
Estimated H-index: 2
(CAS: Chinese Academy of Sciences),
Guoqiang Li5
Estimated H-index: 5
(Beijing Institute of Genomics)
+ 18 AuthorsZhanyang Wang (Yantai University)
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Published on May 23, 2019in bioRxiv
Leslie S. Babonis7
Estimated H-index: 7
(UF: University of Florida),
Joseph F. Ryan22
Estimated H-index: 22
(UF: University of Florida)
+ 1 AuthorsMark Q. Martindale58
Estimated H-index: 58
(UF: University of Florida)
Understanding the drivers of morphological diversity is a persistent challenge in evolutionary biology. Here, we investigate functional diversification of secretory cells in the sea anemone Nematostella vectensis to understand the mechanisms promoting cellular specialization across animals. We demonstrate regionalized expression of gland cell subtypes in the internal ectoderm of N. vectensis and show that adult gland cell identity is acquired very early in development. A phylogenetic survey of t...
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Published on May 1, 2019in Molecular Biology and Evolution 10.22
Timothy Q. DuBuc7
Estimated H-index: 7
(UF: University of Florida),
Joseph F. Ryan22
Estimated H-index: 22
(UF: University of Florida),
Mark Q. Martindale58
Estimated H-index: 58
(UF: University of Florida)
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Published on Jan 15, 2019in bioRxiv
Miguel Salinas-Saavedra3
Estimated H-index: 3
(UF: University of Florida),
Athula H. Wikramanayake6
Estimated H-index: 6
(UM: University of Miami),
Mark Q. Martindale58
Estimated H-index: 58
(UF: University of Florida)
The β-catenin protein has two major known functions in animal cells. It keeps epithelial tissue homeostasis by its connection with Adherens Junctions (AJ), and it serves as a transcriptional co-factor along with Lef/Tcf to enter the nucleus and regulate target genes of the Wnt/β-catenin (cWnt) signaling pathway. To assess the ancestral role of β-catenin during development we examined its distribution and function in the ctenophore Mnemiopsis leidyi (one of the earliest branching animal phyla) by...
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Published on Jan 2, 2019in bioRxiv
Julia Ramon Mateu (Whitney Laboratory for Marine Bioscience), Mark Q. Martindale58
Estimated H-index: 58
(Whitney Laboratory for Marine Bioscience)
It has been known for well over 50 years that ctenophores have the capacity to regenerate but the cellular and molecular mechanisms underlying this ability are unknown. We have studied wound healing and adult regeneration in the ctenophore Mnemiopsis leidyi and show that cell proliferation is activated at the wound site and is indispensable for whole-body regeneration. Wound healing occurs normally in the absence of cell proliferation forming a scar-less wound epithelium. No blastema is generate...
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Published on Dec 1, 2018in Nature Communications 12.35
Timothy Q. DuBuc7
Estimated H-index: 7
(National University of Ireland, Galway),
Thomas B. Stephenson1
Estimated H-index: 1
(UF: University of Florida)
+ 1 AuthorsMark Q. Martindale58
Estimated H-index: 58
(UF: University of Florida)
Hox gene transcription factors are important regulators of positional identity along the anterior–posterior axis in bilaterian animals. Cnidarians (e.g., sea anemones, corals, and hydroids) are the sister group to the Bilateria and possess genes related to both anterior and central/posterior class Hox genes. Here we report a previously unrecognized domain of Hox expression in the starlet sea anemone, Nematostella vectensis, beginning at early blastula stages. We explore the relationship of two o...
9 Citations Source Cite
Published on Dec 1, 2018
David J. Duffy8
Estimated H-index: 8
(Bangor University),
Christine E. Schnitzler16
Estimated H-index: 16
(UF: University of Florida)
+ 10 AuthorsBette Zirkelbach1
Estimated H-index: 1
(Marathon Oil)
Wildlife populations are under intense anthropogenic pressures, with the geographic range of many species shrinking, dramatic reductions in population numbers and undisturbed habitats, and biodiversity loss. It is postulated that we are in the midst of a sixth (Anthropocene) mass extinction event, the first to be induced by human activity. Further, threatening vulnerable species is the increased rate of emerging diseases, another consequence of anthropogenic activities. Innovative approaches are...
3 Citations Source Cite
Published on Nov 1, 2018in Journal of Experimental Marine Biology and Ecology 1.99
Casandra R. Newkirk1
Estimated H-index: 1
(UF: University of Florida),
Thomas K. Frazer23
Estimated H-index: 23
(UF: University of Florida),
Mark Q. Martindale58
Estimated H-index: 58
(Whitney Laboratory for Marine Bioscience)
Abstract The mutualistic relationship between dinoflagellates in the genus Symbiodinium microadriaticum and animals in the phylum Cnidaria, specifically corals, make up one of the most well-known symbioses in the marine environment. The nature of the relationship is such that these symbiotic algae provide products of photosynthesis to their cnidarian hosts, while the algae are afforded refuge within the endodermal cells of the host. Use of the model system Cassiopea xamachana (a.k.a. the ‘upside...
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Published on Sep 29, 2018in bioRxiv
Miguel Salinas-Saavedra3
Estimated H-index: 3
(UF: University of Florida),
Mark Q. Martindale58
Estimated H-index: 58
(UF: University of Florida)
In bilaterians and cnidarians, embryonic and epithelial cell-polarity are regulated by the interactions between Par proteins, Wnt/PCP signaling pathway, and cell-cell adhesion. Par proteins are highly conserved across Metazoa, including ctenophores. But strikingly, ctenophore genomes lack components of the Wnt/PCP pathway and cell-cell adhesion complexes; raising the question if ctenophore cells are polarized by mechanisms involving Par proteins. Here, by using immunohistochemistry and live-cell...
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