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Jamun (Eugenia jambolana Lam.) Fruit Extract Prevents Obesity by Modulating the Gut Microbiome in High‐Fat‐Diet‐Fed Mice

Published on May 1, 2019in Molecular Nutrition & Food Research4.653
· DOI :10.1002/mnfr.201801307
Jialin Xu4
Estimated H-index: 4
(NU: Northeastern University),
Tingting Liu3
Estimated H-index: 3
(NU: Northeastern University)
+ 7 AuthorsLiya Li6
Estimated H-index: 6
(NU: Northeastern University)
Abstract
  • References (46)
  • Citations (3)
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References46
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#1Wenfeng Li (Yangtze Normal University)H-Index: 1
#2Kun Zhang (Jining Medical University)H-Index: 1
Last. Hongyan Yang (Fourth Military Medical University)H-Index: 1
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Consumption of pectin contributes to changes in the gut microbiota and the metabolism of short-chain fatty acids (SCFAs). We aimed to investigate the effects of and mechanism by which pectin prevented nonalcoholic fatty liver disease (NAFLD) in mice that were fed a high-fat diet containing 30% lard (HF). HF-fed mice that orally ingested pectin for 8 weeks exhibited improvements in lipid metabolism and decreased oxidative stress and inflammation through a mechanism regulated by the mitogen-activa...
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#1Patrice D. Cani (UCL: Université catholique de Louvain)H-Index: 80
The microbiome has received increasing attention over the last 15 years. Although gut microbes have been explored for several decades, investigations of the role of microorganisms that reside in the human gut has attracted much attention beyond classical infectious diseases. For example, numerous studies have reported changes in the gut microbiota during not only obesity, diabetes, and liver diseases but also cancer and even neurodegenerative diseases. The human gut microbiota is viewed as a pot...
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#1Jialin Xu (NU: Northeastern University)H-Index: 4
#2Tingting Liu (NU: Northeastern University)H-Index: 3
Last. Liya Li (NU: Northeastern University)H-Index: 6
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The edible berries of Eugenia jambolana Lam. (known as Jamun) are consumed in various parts of the world. Our previous studies revealed that a triterpenoid-enriched Jamun fruit extract (TJFE) showed beneficial effects on glucose homeostasis in non-diabetic mice. Herein, the anti-diabetic effects of TJFE (100 mg kg−1 by oral gavage for ten days) were evaluated in streptozotocin (STZ)-induced type 1 diabetic mice. TJFE significantly attenuated STZ-induced hyperglycemia and glucose intolerance, sup...
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#1Wei-Ling Guo (Fujian Agriculture and Forestry University)H-Index: 5
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The objective of this study was to investigate the effects of ethanol extract of Ganoderma lucidum (GL95) on hyperlipidaemia and gut microbiota, and its regulation mechanism in Wistar rats fed on a high-fat diet (HFD). UPLC-QTOF MS indicated that GL95 was enriched with triterpenoids, especially ganoderic acids. The results of the animal experiment showed that oral administration of GL95 markedly alleviated the dyslipidemia through decreasing the levels of serum total triglyceride (TG), total cho...
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#1Yiwei Qian (SJTU: Shanghai Jiao Tong University)H-Index: 5
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Abstract Emerging evidences suggest that gut microbiota dysbiosis plays a role in Parkinson’s disease (PD). However, the alterations in fecal microbiome in Chinese PD patients remains unknown. This case-control study was conducted to explore fecal microbiota compositions in Chinese PD patients. Microbiota communities in the feces of 45 patients and their healthy spouses were investigated using high-throughput Illumina Miseq sequencing targeting the V3-V4 region of 16S ribosomal RNA (rRNA) gene. ...
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The intestinal microbial communities play critical roles in various aspects of body function of the host. Prebiotics, such as dietary fiber, can affect health of the host by altering the composition of intestinal microbiota. Although brown seaweed Laminaria japonica (L. japonica) is rich in dietary fiber, studies on its prebiotic potential are quite rare. In the present study, basal diet supplemented with dried L. japonica (DLJ), heated dried L. japonica (HLJ), or heated dried L. japonica with a...
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Gut microbiome has been identified in the past decade as an important factor involved in obesity, but the magnitude of its contribution to obesity and its related comorbidities is still uncertain. Among the vast quantity of factors attributed to obesity, environmental, dietary, lifestyle, genetic, and others, the microbiome has aroused curiosity, and the scientific community has published many original articles. Most of the studies related to microbiome and obesity have been reported based on th...
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#1Teresa Requena (CSIC: Spanish National Research Council)H-Index: 35
#2M. C. Martínez-Cuesta (CSIC: Spanish National Research Council)H-Index: 10
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Diet has shaped microbiota profiles through human evolution. Traditional gut microbiomes are described to be driven by high levels of Prevotella. In the present, however, it is consistently described a lower microbial richness in urban industrialized populations compared with individuals living in rural settings, Bacteroides being predominant among urban-industrial gut microbiomes. Components of diet are highly influential in shaping the gut microbiota, being fiber, fat, proteins, polyphenols an...
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#1Junli MaH-Index: 1
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The gut microbiota plays critical roles in development of obese-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes(T2D), and insulin resistance(IR), highlighting the potential of gut microbiota-targeted therapies in these diseases. There are various ways that gut microbiota can be manipulated, including through use of probiotics, prebiotics, synbiotics, antibiotics, and some active components from herbal medicines. In this review, we review the main role...
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#1Wen Liu (SJTU: Shanghai Jiao Tong University)H-Index: 34
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cope : Obesity and associated metabolic complications is a worldwide public health issue. Gut microbiota has been recently linked to obesity and its related inflammation. In this study, we have explored the anti-inflammatory effect of grape seed proanthocyanindin extract (GSPE) in the high-fat diet (HFD)-induced obesity and identified the contribution of the gut microbiota to GSPE effects on metabolism. Methods and results : Mice were fed a normal diet and a high-fat diet with or without GSPE (3...
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With >70,000 yearly publications using mouse data, mouse models represent the best engrained research system to address numerous biological questions across all fields of science. Concerns of poor study and microbiome reproducibility also abound in the literature. Despite the well-known, negative-effects of data clustering on interpretation and study power, it is unclear why scientists often house >4 mice/cage during experiments, instead of ≤2. We hypothesized that this high animal-cage-density ...
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Obesity, defined as excessive fat accumulation that may impair health, has been described throughout human history, but it has now reached epidemic proportions with the WHO estimating that 39% of the world’s adults over 18 years of age were overweight or obese in 2016. Obesity is a chronic low-grade inflammatory state leading to organ damage with an increased risk of common diseases including cardiovascular and metabolic disease, non-alcoholic fatty liver disease, osteo-arthritis and some cancer...
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The negative effects of data clustering due to (intra-class/spatial) correlations are well-known in statistics to interfere with interpretation and study power. Therefore, it is unclear why housing many laboratory mice (>4), instead of one-or-two per cage, with the improper use/reporting of clustered-data statistics, abound in the literature. Among other sources of 9artificial9 confounding, including cyclical oscillations of the 9cage microbiome9, we quantified the heterogeneity of modern husban...
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Abstract The aim of this study was to investigate the effects of extruded sorghum flour (ESF) on rats fed with a high-fat diet (HFD) on gut microbiota modulation, inflammation, and oxidative stress. Male Wistar rats were fed a normal diet (AIN-93 M, n = 8), HFD (n = 8), or HFD plus ESF replacing 50% cellulose and 100% corn starch (HFDS50, n = 8) or HFD plus ESF replacing 100% cellulose and 100% corn starch (HFDS100, n = 8) for eight weeks. ESF improved the composition of intestinal microbiota by...
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