HDAC9 complex inhibition improves smooth muscle–dependent stenotic vascular disease
Abstract
Patients with heterozygous missense mutations in the ACTA2 or MYH11 gene are known to exhibit thoracic aortic aneurysm and a risk of early-onset aortic dissection. However, less common phenotypes involving arterial obstruction are also observed, including coronary and cerebrovascular stenotic disease. Herein we implicate the HDAC9 complex in transcriptional silencing of contractile protein-associated genes, known to undergo downregulation in...
Paper Details
Title
HDAC9 complex inhibition improves smooth muscle–dependent stenotic vascular disease
Published Date
Jan 24, 2019
Journal
Volume
4
Issue
2
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