Palmitoylation of Claudin-5 Proteins Influences Their Lipid Domain Affinity and Tight Junction Assembly at the Blood–Brain Barrier Interface

Post-translational lipid modification of integral membrane proteins is recognized as a key mechanism to modulate protein–protein and membrane–protein associations. Despite numerous reports of lipid-modified proteins, molecular-level understanding of the influence of lipid-modification of key membrane proteins remains elusive. This study focuses on the lipid modification of one such protein—claudin-5, a critical component of the blood–brain...