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Nandhini Rajagopal
Syracuse University
BiophysicsMembrane proteinPalmitoylationIntegral membrane proteinChemistry
4Publications
3H-index
18Citations
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Publications 4
Newest
#1Nandhini Rajagopal (SU: Syracuse University)H-Index: 3
#2Alejandro J. Durand (SU: Syracuse University)H-Index: 1
Last. Shikha Nangia (SU: Syracuse University)H-Index: 15
view all 3 authors...
Biological systems exhibit diverse examples of controlled solute permeability and selectivity in cell and tissue barriers. The epithelial and endothelial cells lining each organ confer selectivity via tight junctions, physical fence-like structures that regulate paracellular transport, whose primary functional component is a claudin. Members of the claudin family of proteins undergo cis and trans assembly to control paracellular selectivity. However, based on the type of claudin and its expressi...
1 CitationsSource
#1Nandhini Rajagopal (SU: Syracuse University)H-Index: 3
#2Flaviyan Jerome Irudayanathan (SU: Syracuse University)H-Index: 6
Last. Shikha Nangia (SU: Syracuse University)H-Index: 15
view all 3 authors...
The selectivity of the blood–brain barrier (BBB) is primarily maintained by tight junctions (TJs), which act as gatekeepers of the paracellular space by blocking blood-borne toxins, drugs, and pathogens from entering the brain. The BBB presents a significant challenge in designing neurotherapeutics, so a comprehensive understanding of the TJ architecture can aid in the design of novel therapeutics. Unraveling the intricacies of TJs with conventional experimental techniques alone is challenging, ...
5 CitationsSource
#1Nandhini Rajagopal (SU: Syracuse University)H-Index: 3
#2Shikha Nangia (SU: Syracuse University)H-Index: 15
Integral membrane proteins are ubiquitous in biological cellular and subcellular membranes. Despite their significance to cell function, isolation of membrane proteins from their hydrophobic lipid environment and further characterization remains a challenge. To obtain insights into membrane proteins, computational approaches such as docking or self-assembly simulations have been used; however, the promise of these approaches have been limited due to the computational cost. Here we present a new ...
3 CitationsSource
#1Nandhini Rajagopal (SU: Syracuse University)H-Index: 3
#2Flaviyan Jerome Irudayanathan (SU: Syracuse University)H-Index: 6
Last. Shikha Nangia (SU: Syracuse University)H-Index: 15
view all 3 authors...
Post-translational lipid modification of integral membrane proteins is recognized as a key mechanism to modulate protein–protein and membrane–protein associations. Despite numerous reports of lipid-modified proteins, molecular-level understanding of the influence of lipid-modification of key membrane proteins remains elusive. This study focuses on the lipid modification of one such protein—claudin-5, a critical component of the blood–brain barrier tight junctions. Claudin-5 proteins are responsi...
3 CitationsSource
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