Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody
Abstract
The angiotensin II (AngII) type 1 receptor (AT1R) is a critical regulator of cardiovascular and renal function and is an important model for studies of G-protein-coupled receptor (GPCR) signaling. By stabilizing the receptor with a single-domain antibody fragment ("nanobody") discovered using a synthetic yeast-displayed library, we determined the crystal structure of active-state human AT1R bound to an AngII analog with partial agonist activity....
Paper Details
Title
Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody
Published Date
Jan 1, 2019
Journal
Volume
176
Issue
3
Pages
479 - 490.e12
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