OP0289 Integration of chromatin conformation, transcriptome and genome-wide landscape of brd2 and brd4 binding motifs identifies mechanisms of bet inhibitor action in rheumatoid arthritis synovial fibroblasts

Background

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by infiltration of immune cells into the synovium and hyperplasia of the synovial lining, resulting in the formation of pannus that degrades cartilage and bone. Fibroblast-like synoviocytes (FLS) are the main cell types of the rheumatoid synovium and possess phenotypic and molecular characteristics of transformed cells. JQ1, an inhibitor of the...