Sleep–wake regulation and the hallmarks of the pathogenesis of Alzheimer’s disease

While efficient treatments for Alzheimer’s disease (AD) remain elusive, a growing body of research has highlighted sleep–wake regulation as a potential modifiable factor to delay disease progression. Evidence accumulated in recent years is pointing toward a tight link between sleep–wake disruption and the three main hallmarks of the pathogenesis of AD, i.e. abnormal amyloid-beta (Aβ) and tau proteins accumulation, and neurodegeneration. However,...