Original paper
Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
Abstract
Drugs that modify the epigenome are powerful tools for treating cancer, but these drugs often have pleiotropic effects, and identifying patients who will benefit from them remains a major clinical challenge. Here we show that medulloblastomas driven by the transcription factor Gfi1 are exquisitely dependent on the enzyme lysine demethylase 1 (Kdm1a/Lsd1). We demonstrate that Lsd1 physically associates with Gfi1, and that these proteins cooperate...
Paper Details
Title
Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
Published Date
Jan 18, 2019
Journal
Volume
10
Issue
1
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Notes
History