Inhaled nitric oxide to treat intermediate risk pulmonary embolism: A multicenter randomized controlled trial

To test the hypothesis that adjunctive inhaled NO would improve RV function and viability in acute PE. This was a randomized, placebo-controlled, double blind trial conducted at four academic hospitals. Eligible patients had acute PE without systemic arterial hypotension but had RV dysfunction and a treatment plan of standard anticoagulation. Subjects received either oxygen plus 50 parts per million nitrogen (placebo) or oxygen plus 50 ppm NO...