Review paper
Cellular Senescence: Aging, Cancer, and Injury
Abstract
Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that prevents the cells to acquire an unnecessary damage. The senescent state is accompanied by a failure to re-enter the cell cycle in response to mitogenic stimuli, an enhanced secretory phenotype and resistance to cell death. Senescence takes place in several...
Paper Details
Title
Cellular Senescence: Aging, Cancer, and Injury
Published Date
Apr 1, 2019
Journal
Volume
99
Issue
2
Pages
1047 - 1078
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