Original paper
The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis
Abstract
Mitochondrial topoisomerase IB (TOP1MT) is a nuclear-encoded topoisomerase, exclusively localized to mitochondria, which resolves topological stress generated during mtDNA replication and transcription. Here, we report that TOP1MT is overexpressed in cancer tissues and demonstrate that TOP1MT deficiency attenuates tumor growth in human and mouse models of colon and liver cancer. Due to their mitochondrial dysfunction, TOP1MT-KO cells become...
Paper Details
Title
The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis
Published Date
Jan 8, 2019
Journal
Volume
10
Issue
1
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Notes
History