Spectrum of GABAA receptor variants in epilepsy

Purpose of review Recent publications point to an increasingly important role of variants in genes encoding GABA A receptor subunits associated with both common and rare forms of epilepsies. The aim of this review is to give an overview of the current clinical phenotypes, genetic findings and pathophysiological mechanisms related to GABA A receptor variants. Recent findings Early work showed that inherited variants in GABRG2 and GABRA1 cause...