Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4
Abstract
MLL3 and MLL4 are two closely related members of the SET1/MLL family of histone H3K4 methyltransferases and are responsible for monomethylating histone H3K4 on enhancers, which are essential in regulating cell-type-specific gene expression. Mutations of MLL3 or MLL4 have been reported in different types of cancer. Recently, the PHD domains of MLL3/4 have been reported to recruit the MLL3/4 complexes to their target genes by binding to histone H4...
Paper Details
Title
Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4
Published Date
Jan 3, 2019
Journal
Volume
10
Issue
1
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