Original paper
PF74 Inhibits HIV-1 Integration by Altering the Composition of the Preintegration Complex
Abstract
The HIV-1 capsid protein (CA) facilitates reverse transcription and nuclear entry of the virus. However, CA's role in post-nuclear entry steps remains speculative. We describe a direct link between CA and integration by employing the capsid inhibitor PF74 as a probe coupled with the biochemical analysis of HIV-1 preintegration complexes (PICs) isolated from acutely infected cells. At a low micromolar concentration, PF74 potently inhibited HIV-1...
Paper Details
Title
PF74 Inhibits HIV-1 Integration by Altering the Composition of the Preintegration Complex
Published Date
Mar 15, 2019
Journal
Volume
93
Issue
6
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Notes
History