Original paper
Conformational selection turns on phenylalanine hydroxylase
Volume: 293, Issue: 51, Pages: 19544 - 19545
Published: Dec 1, 2018
Abstract
Phenylalanine hydroxylase catalyzes a critical step in the phenylalanine catabolic pathway, and impairment of the human enzyme is linked to phenylketonuria. Phenylalanine is also a positive allosteric regulator of the enzyme, and the allosteric binding site has been determined by crystallography. However, the allosteric activation mechanism remains unclear. Using large-scale simulations to explore how phenylalanine binds to the regulatory site,...
Paper Details
Title
Conformational selection turns on phenylalanine hydroxylase
Published Date
Dec 1, 2018
Volume
293
Issue
51
Pages
19544 - 19545
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