DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase
Abstract
Fusion of critically short or damaged telomeres is associated with the genomic rearrangements that support malignant transformation. We have demonstrated the fundamental contribution of DNA ligase 4-dependent classical non-homologous end-joining to long-range inter-chromosomal telomere fusions. In contrast, localized genomic recombinations initiated by sister chromatid fusion are predominantly mediated by alternative non-homologous end-joining...
Paper Details
Title
DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase
Published Date
Dec 21, 2018
Journal
Volume
47
Issue
5
Pages
2402 - 2424
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Notes
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