Original paper
APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy
Abstract
Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance. PD-L1/PD-1 checkpoint immunotherapy is a highly promising approach to overcome these protective signals and induce tumor shrinkage. Yet, the nature of the neo-antigens driving those beneficial responses remains unclear. Here, we show that...
Paper Details
Title
APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy
Published Date
Dec 24, 2018
Journal
Volume
8
Issue
3
Pages
1550341 - 1550341
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Notes
History