Original paper
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche
Abstract
In many tissues, homeostasis is maintained by physical contact between stem cells and an anatomically defined niche. However, how stem cell homeostasis is achieved in environments where cells are motile and dispersed among their progeny remains unknown. Using murine spermatogenesis as a model, we find that spermatogenic stem cell density is tightly regulated by the supply of fibroblast growth factors (FGFs) from lymphatic endothelial cells. We...
Paper Details
Title
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche
Published Date
Jan 1, 2019
Journal
Volume
24
Issue
1
Pages
79 - 92.e6
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Notes
History