Fine needle aspirates comprehensively sample intrahepatic immunity

In order to refine new therapeutic strategies in the pipeline for HBV cure, evaluation of virological and immunological changes compartmentalised at the site of infection will be required. We therefore investigated if liver fine needle aspirates (FNAs) could comprehensively sample the local immune landscape in parallel with viable hepatocytes.Matched blood, liver biopsy and FNAs from 28 patients with HBV and 15 without viral infection were...